Well, some German researchers think so. They say they’ve found a compound, methylpyridinium, that boosts the activity of phase II enzymes which are believed to protect against colon cancer. They’ve just done lab tests so far, so there is no good information on exactly how MUCH coffee would need to be consumed to provide a measurable benefit. One thing they did note, however, was that espresso-style coffee contains two to three times more of this compound than a medium roast coffee (mainly because methylpyridinium is formed during the roasting process, it’s not present in green beans – so, the longer roast associated with espresso beans has the by product of more of this compound produced). (link).